What is Wegovy?
Wegovy (semaglutide) injection is a prescription medicine used for weight loss in obese adults and teenagers, or overweight adults with other weight-related medical issues. Wegovy works by regulating appetite and reducing calorie intake, leading to weight loss and helping with weight management.
Wegovy belongs to the class of drugs called GLP-1 receptor agonists. GLP-1 receptor agonists are a manufactured version of GLP-1, a naturally occurring hormone in the body that acts in several areas in the brain to regulate food intake. When Wegovy is administered, it activates the GLP-1 receptors in the brain. This lowers appetite, reducing the calories consumed, leading to weight loss.
This medicine should be used together with a decreased-calorie meal plan and increased physical activity to help weight management.
Wegovy is given as an injection under the skin (subcutaneous injection) once a week.
What is Wegovy used for?
Wegovy is an FDA-approved anti-obesity medicine to be used by people 12 years and older for chronic weight management when used together with a reduced-calorie diet and increased physical activity.
Wegovy is indicated for use in:
- Obese (BMI of 30 kg/m2 or greater)
- Overweight (BMI of 27 kg/m2 or greater) and have medical problems (e.g.high blood pressure, type 2 diabetes, or high cholesterol) due to your weight.
Pediatric (12 years and older):
- Obese (initial BMI 95th percentile or greater for age and sex)
Wegovy contains semaglutide which is the same active ingredient in Ozempic and Rybelsus, therefore these products should not be used together. Ozempic (subcutaneous weekly injection) and Rybelsus (once-a-day tablet) are used lower blood sugar levels for type two diabetic patients. Ozempic is also used to lower the risk of major cardiovascular events for some type 2 diabetic patients.
Call your doctor at once if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, a hoarse voice, or shortness of breath. In studies with rodents, Wegovy and medicines that work like Wegovy caused thyroid tumors, including thyroid cancer. It is not known if this medicine will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
You should not use this medicine if you have tumors in your glands called multiple endocrine neoplasia type 2 (MEN 2), or a personal or family history of medullary thyroid cancer (MTC).
Before taking this medicine
You should not use Wegovy if you are:
- allergic to it or any of the ingredients. See the end of this page for a complete list of ingredients. Symptoms of a serious allergic reaction include swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, feeling dizzy or lightheaded, and a very rapid heartbeat.
- multiple endocrine neoplasia type 2 (tumors in your glands); or
- a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer).
Tell your doctor if you have ever had:
- a stomach or intestinal disorder;
- kidney disease;
- eye problems caused by diabetes (diabetic retinopathy);
- have or have had depression or suicidal thoughts, or other mental health issues.
In animal studies, semaglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people. Ask your doctor about your risk.
You should stop using this medicine at least two months before you plan to get pregnant. This medicine may harm your baby. Ask your doctor for a safer medicine to use during this time. Controlling diabetes is very important during pregnancy, as is gaining the right amount of weight. Even if you are overweight, losing weight during pregnancy could harm the unborn baby.
There is a pregnancy exposure registry for women who use Wegovy during pregnancy. The reason for this registry is to collect information about the health of you and your baby. Talk to your doctor about how you can take part in this registry, or you may contact Novo Nordisk at 1-800-727-6500.
Tell your healthcare professional if you are breastfeeding or planning to breastfeed. It is unknown if this medicine passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using this medicine.